The 23-test forward is suffering from a hamstring injury and will be replaced by Alistair Hargreaves, who has played twice for his country. Ryan Kankowski replaces Hargreaves on the bench.
The Springboks left 21 frontline players back in South Africa because of injury and will give debuts to three players with another uncapped player on the bench.

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Replacements: 16-Chiliboy Ralepelle, 17-CJ van der Linde, 18-Ryan Kankowski, 19-Jean Deysel, 20-Charl McLeod, 21-Adrian Jacobs, 22-Patrick Lambie.